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Protein Phosphorylation
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Protein Phosphorylation Profiling

Typical Scenario I

Dr. Frank had been studying the pathology of diabetes for 5 years. Using a number of different models including knock-out mice and diabetic rats, he had generated some very interesting results. However, he needed a global view of the changes in various signaling pathways in those models so he could achieve a more complete picture of different proteins and pathways involved in the etiology of diabetes.  He then came across AntibodyArraysTM and was able to utilize this new technique to perform a fast screening on the phosphorylation patterns of hundreds of well-studied cellular proteins and found quite a few interesting molecules.

With protein phosphorylation profiling by AntibodyArraysTM, scientists can get a quick read on what proteins have been phosphorylated (therefore their activities changed), so they could focus their next stages of research on proteins that are most likely to be involved.


Typical Scenario II

A Group Leader in a pharmaceutical company was deliberating on which lead she should move to the next stage of development. Her group had identified a number of chemical entities through high-throughput screening and found that these molecules bind to the target with good affinity, but she knew something was missing: She needed to understand whether those chemicals also have effects on other cellular proteins.  This information would help her determine the selectivity and toxicity of drug leads.

She chose to use AntibodyArraysTM to help in her assessment of the situation. By comparing the difference in protein phosphorylations between untreated cells and cells treated with the drug leads, she gained insight on the specificity of each lead and made an informed decision on the next step of the development.


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