PCB Technology
Proteins
are important components of cells and their activities determine various
cellular functions; and detection of proteins is indispensable in biomedical
research and clinical applications.
Protein
cycling
binding (PCB) technology is a method
developed by Hypromatrix that can rapidly and sensitively detect proteins as well
as other molecules. PCB utilizes a
repeated filtration-like process to achieve rapid and efficient protein
binding. In general the method employs multiple cycles/passages of an antibody
solution through an antigen-immobilized porous support. In each cycle, the
antibody solution passes through the porous support via a filtration-like
process; during the passage the antibody have the chance of binding the
antigens; then the solution is passed through the porous support again in the
next cycle. This process is repeated multiple times; and thus dramatically
increases the binding between antibodies and antigens.
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